Trade Routes of the Post-Classical World Essay Sample free essay sample

From 600 to 1400 C. E. . two indispensable trade paths of the Post-Classical universe were the Silk Roads and that of the Indian Ocean Basin. which were both huge webs of many ancient paths associating assorted finishs within their intricate systems of trade and exchange. Each of these trade paths yielded highly legion effects and deductions for the hereafter that would impact life on Earth for many old ages to come—and these effects are similar for the major trade paths of the Silk Roads and the Indian Ocean Basin with societal respects to the fact that both paths majorly influenced the important spread of faiths and. therefore. civilizations ; nevertheless. the effects are really different with respects to the ensuing chances for cross-cultural brushs due to the fact that the Silk Road’s spreading of epidemic disease diminished these brushs and the Indian Ocean Basin’s command of sailing techniques allowed for abundant trade to ensue in a rich overplus of cross -cultural exchange. We will write a custom essay sample on Trade Routes of the Post-Classical World Essay Sample or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Both the trade and exchange happening through the Silk Roads and through the Indian Ocean Maritime webs resulted in the spread of faiths. In both instances. this is because the huge webs of roads were a medium for merchandisers coming from fatherlands of imperially sponsored faiths to merchandise and set up communities where they would advance their religion along the manner. in order that mission work might be accomplished and so that common cultural imposts between their ain state and the foreign lands with which they trade would make a peaceable relationship in which both parties would profit from common regard and apprehension. From 200 B. C. to 700 C. E. on the Silk Roads. Buddhism was the most outstanding and popular religion among the traveling merchandisers due to emperor Ashoka’s imperial sponsorship back in India. The religion foremost started to pull converts in legion oasis towns. where the merchants—along with their full caravans—found safety in the signifier of nutrient. H2O. shelter. and markets. These oasis towns allowed the merchandisers to construct Buddhist monasteries. which all owed the oasis towns to go widely distributed centres that majorly supported Buddhism. From here. Buddhism spread to the steppe lands of cardinal Asia and even further to China. Japan. and Korea. In add-on. Hinduism besides spread through the Indian Merchants going to Southeast Asia on the Silk Roads. Many swayers of Southeast Asia and other assorted islands near Asia such as Sumatra and Java either converted to Buddhism or promoted the Hindu Cults. engaging advisers of these faiths and edifice monasteries and temples. Furthermore. Christianity and Manichaeism besides established bridgeheads in parts of Asia and the Mediterranean Basin due to the handiness of huge webs of roads on which missionaries of these faiths could go. On the other manus. the traveling of merchandisers and peoples of assorted civilizations which led to the establishing of new faiths besides occurred through the exchange in the Indian Ocean Basin trade web. From the seventh century through the fifteenth century. Muslim merchants—that were posterities of Persian and Arab Mariners during the times of Muhammad himself— dominated transit and trade webs between India and other lands. As they traded. they took upon themselves the rules of jehad and established diaspora communities and married adult females of different civilizations along the trade paths so that the entreaty of Islam would go more outstanding in Indian communities as the medium was more through trade than merely suppressing ; as suppressing would of course raise a negative impact. Some Indians converted to Islam right off. trusting to derive a higher place in society ; nevertheless. others did non accept Islam so easy. The Islamic Sufi mystics that sailed through the Indian Ocean Basin with trading merchandisers developed a more popular and widespread followers of Islamic civilization and faith in India. On the contrary to this major similarity. the direct effects and long-run impacts of the highly important and huge trade webs of the Silk Roads and the Indian Ocean Basin face a notable difference in that. after the extremum of the usage of the Silk Roads. cross-cultural brushs between civilisatio ns really began to worsen ; whereas with the Indian Ocean Trade Networks. cross-cultural brushs reached a extremum after the flood tide of its usage. What is meant by this is that. because of the epidemics of diseases brought approximately by the Silk Roads. this demographic diminution brought approximately negative economic and societal alteration in bend. Once the trade within the imperiums of China and of Rome declined due to awful epidemics of variola. rubeolas. and of class the ill-famed bubonic plague—killing 1000000s upon 1000000s of people— the antecedently incorporate economic systems of China and Rome were automatically transformed into progressively self-sufficing regional economic systems. This of class led to a complete deficiency of cross-cultural brushs and trade. which has shown itself to be the prototype of successful imperiums and civilisations in the larger universe. And it is because of this deficiency of cross-cultural exchange and support that serious instability occurred in China after the Han dynasty prostration ; and finally in the Mediterranean—the autumn of the western Roman imperium . In the instance of the Indian Ocean Basin Trade webs. the state of affairs of epidemic disease taking to a deficiency of cross-cultural brushs did non happen. On the reverse. after the extremum of its usage. the Indian Ocean Basin achieved abundant cross-cultural brushs and exchange due to a command of sailing techniques. and therefore a mostly productive and active trading economic system due to the maritime advantages achieved by certain naval finds. For illustration. larger ships such as the dhows—favored by Arab. Persian. and Indian merchandisers and sailors—and Asiatic debriss. were big and could therefore travel more swimmingly and expeditiously through the Waterss. In add-on. the magnetic compass. invented by the Chinese. every bit good as the Lateen sails both allowed for more efficient travel every bit good. which of course heightened the usage of maritime travel and trade. These naval advantages were particularly put into action when trade majorly heightened after the constitution of the Umayyad dynasty and the Abbasid dynasty. and its effects were really significantly witnessed upon the constitution of specialised production due to increased trade in the Indian Ocean Basin after that. Overall. these huge webs of trade and exchange of the Silk Roads and the Indian Ocean Basin resulted in legion long-run effects that doubtless changed the class of history. Whether it was the spread of epidemics and diseases o r the debut of new engineerings and trades. these effects yielded dramatic effects for the universe during the clip of 600-1400 C. E. . and much further into the hereafter as good.

Joseph Goebbles Minister for Propaganda essays

Joseph Goebbles Minister for Propaganda essays Paul Joseph Goebbles was born on the 29th October 1897, in Rheydt, in the Rhineland. His father was a pheasant farmer, and his mother was a French woman. Both of his parents were strict Roman Catholics. Goebbles was extremely academically successful throughout his life. This compensated for his physical appearance. He had a crippled foot and a permanent limp. These inadequacies affected him psychologically, and he felt that he could not ''serve his country'' in the First World War when he was rejected from the German army because of his deformity. This was a taunt that stayed with him all of his life. As his pursuits to serve his country in the war failed to succeed, Goebbles dedicated his time and energy to studying. For three years (1917 - 1921), he studied germanics, history, literature, and philosophy, in Freiburg, Bonn, Wurzburg, Cologne, Munich, and Heidelburg. In Heidelburg, Goebbles studied forma Jewish historian of literature. This disadvantaged him later in his career, as people called him a ''pupil of the Jesuits, and a half French man''. This indicated that he was not of pure German blood. This contradicted his work, as his job was to turn people against the Jews, and to make a population of 'blonde-haired and blue-eyed' people. After World War 1, Goebbles tried to become a write, but his books, were unpopular, and so he tried to be journalist. The next year, he was appointed as business manager of the North Rhineland. During this time, Goebbles became increasingly involved in politics. Goebbles became the leading propagandist for the Nazi party during the 1930's. He first heard Hitler speak in 1922, in Munich. At once, he recognised the man as being similar to himself. Both had had false starts in life, both men had the same ambition of being popular, and having their opinions and thoughts listened to and agreed by others. Goebbles befriended Hitler, in his attempt to reach the top. He ...

Quatitative Data Anaylsis Research Paper Example | Topics and Well Written Essays - 1000 words

Quatitative Data Anaylsis - Research Paper Example The study type would be quantitative; the researcher will circulate a questionnaire to gather data on the tested variables. This primarily is a correlation study, since the researcher is interested in discerning the important variables associated with the phenomenon. The researcher will conduct this study in a non-contrived setting because the researcher is interested in assess the working of these variables in a natural setting. Moreover, this type of study can be classified as a field study as the researcher will have to visit the organizations in order to understand the working of these variables. The survey tool used is a questionnaire that was developed by another researcher by the name of Bass (Obiwuru, Okuw, Akpa, and Nwankwere, 2011). Variables: Independent Variables: Transformational Leadership: this type of leadership evokes underlying emotions about work in the employees and motivates them to go beyond their current level of work. Transactional leadership: this type of lea dership considers reward as an appropriate return for a certain piece of work from the employees. Dependent Variables: Employee extra effort Employee work satisfaction and effectiveness Employee productivity and loyalty. Hypothesis: Ho: there is no relationship between leadership style and organizational performance of small enterprises. Ha: there is a relationship between leadership style and organizational performance of small enterprises. ... Tool used to measure the independent variable: In this research, the researcher made use of E-views software to understand the relationship of independent and dependent variables. The data collected was coded in order to enter the stats into the statistical software. Statistical Assumptions of Regression Analysis: The reason behind the use of this tool is to make a model of the variables of the study and analyze the changes that happen in a dependent variable when one of the independent variable changes. Linear regression also finds its utility when a researcher wants to use a predictive model to analyze an observed data set. Also a regression analysis is used when a researcher is up against a data that is linear, has a weak exogeneity, constant variance, and lack multi-co linearity. Statistical Results of the hypothesis: Transactional leadership Style: Coefficient of determination=R2 = 0.486445 F-Test= 1.8944 Transformational leadership Style: Coefficient of determination=R2 = 0.968 929 F-Test= 109.144 Characteristics of the data: The data collected through the questionnaire is quantitative figures. Since each variable was ascribed a code after incorporating it in the questionnaire, therefore this data collect is in coded form and behind every code is a variable. Once data gets arranged in a tabular form, the codes are decoded and actual variables are substituted in their place to reveal the true nature of the relationship. Appropriateness of the Statistical procedure: Since the data collect has multiple variables behind it, which are defining the relationship between independent and dependent variable, therefore it is important to see the collective impact of these variables. So a multiple

Interpretation of koan Essay Example | Topics and Well Written Essays - 500 words

Interpretation of koan - Essay Example We must realize that every being that exists has come to be, because the Universal Power willed it to. So every living being is unique and important. The power that created it will also provide for it and nurture it. Therefore, there is no need to be overly anxious about the future, and our sustenance. Our Creator will provide for us. There are many among us who are overanxious about unimportant things like how we should clothe ourselves, in order perhaps to create a favorable impression on others. We forget that being natural and simple has a greater appeal to the esthetic sense than being ostentatious. The flowers in nature in their natural simplicity are as attractive-or even more-than a king decked out in all his finery. If we are mindful of our own true natures, and remain as close to them as our Creator willed us to be, then we need no embellishment. All we need is trust and faith in the Lord that we shall be provided for. If we seek the Lord with sincerity we shall find him. Think of this-if we seek anything in life and seek it with single mindedness and in humility, we shall have what we seek. And remember the virtue of sharing. What we have is to be shared with others. We need not be greedy and crave more than our due. And if we share, so will others share with us, and our needs will be met. In Buddhism the value of poverty should not be underesti

Historical Perspectives on motivation Essay Example | Topics and Well Written Essays - 3000 words

Historical Perspectives on motivation - Essay Example Motivation, the drive to satisfy a need, ultimately comes from within an individual. The job of a manager is to find each worker's commitment, encourage it, and focus it on some common goal.2 Huit (2001) cites that there is a general consensus from a variety of psychology textbooks that motivation is an internal state or condition (sometimes described as a need, desire, or want) that serves to activate or energize behavior and gives it direction. The following are Huit's description of motivation: (1) internal state or condition that activates behavior and gives it direction; (2) desire or want that energizes and directs goal-oriented behavior; and (3) influence of needs and desires on the intensity and direction of behavior. Frank (1994) also adds to Huit's list of descriptions by quoting that the arousal, direction, and persistence of behavior. However, Huit notes that many researchers are now beginning to acknowledge that the factors that energize behavior are likely different from the factors that provide for its persistence. Early studies on management include the book written by the so-called "Father of Scientific Management" himself Frederick Taylor, entitled The Principles of Scientific Management, published in 1911. ... This is in line with the dogma of scientific management, which posits that the way to increase productivity is to look into the most efficient ways of doing things and then teaching workers these methods. Jobs are detailed in such a way that each worker has a specified, well controlled task that can be performed as instructed. Specific procedures and methods for each job must be followed with no exceptions.3 Scientific management viewed people as machines that needed to be properly programmed and had little concern for the psychological or human aspects of work. Presently, much emphasis in some companies is still placed on conformity to work rules rather than on creativity, flexibility, and responsiveness. 4 Taylor's approach in his method included the following: time, methods and the rules of work. In progress to Taylor's efforts, time-motion studies involved breaking down the tasks needed to do a job and measure the time needed to do each task. One of Taylor's famous experiments includes increasing the output of a worker loading pig iron to a rail car. Taylor broke the job down into its smallest constituent movements, timing each one with a stopwatch. The job was remodeled with a decreased number of motions as well as effort and the risk of error. Rest periods of specific interval and duration and a differential pay scale were also used to improve the output. With scientific management, Taylor increased the worker's output from 12 to 47 tons per day! The Taylor model gave rise to dramatic productivity increases.5 Henry L. Gant, on of Taylor's followers, developed GANTT CHARTS by which managers plotted the work of employees a day in advance. It consists of a table of project task information and a bar chart that graphically displays project schedule, depicting

What Genetic Factors Contribute to Obesity?

What Genetic Factors Contribute to Obesity? Obesity has increasingly become a challenging epidemic and is now a global concern which has shown no sign of lessening (McAllister et al, 2009, p. 868). While considerable efforts have been invested in stressing the importance of physical activity and the choice of food intake, studies have shown compelling evidence that genetic determinants brought by the inter-individual differences have high responsibility in obesity susceptibility (ORahilly Farooqi, 2006, p.1095). Substantive evidences about the molecular constituents of the major pathways involved in the balance of mammalian energy have only been recently deciphered. Therefore, this provides a gateway to a mechanistic understanding of obesity that will soon be a useful resource in the designing of effective drugs against obesity. Linkage studies and associations based on populations have identified specific loci where genetic variations occur among obese individuals. Efforts to indentifying and characterizing the monogenic obe sity syndromes have also shown considerable success (ORahilly Farooqi, 2006, p.1095). While a number of researchers have come into a consensus that genetic factors predispose individuals to obesity, some still slightly differ by appreciating the role of such factors like the influence on metabolic rate as well as the effect of selective partitioning of the excess energy in the human body into fats (ORahilly Farooqi, 2006, p.1095). This paper specifically identifies various genetic factors which contribute to obesity and provides recommendations for addressing the epidemic. To date, there are five main constituent genes known to be involved in food intake and energy expenditure pathways which ultimately contribute to obesity progression. These genes are leptin, leptin receptor, melanocortin-4 receptor, pro-opiomelanocortin as well as prohormone convertase genes (Bouchard, 2009, p.1499). The role of these genes in the occurrence of obesity and mutation consequences of such genes, wh ich are studied in different experiments, are elaborated and explained under different gene headings below. Leptin gene Efforts to perform leptin gene cloning in 1994 opened an avenue for rapid research in biomedicine and large scale genetic studies followed thereafter (Hinney, Vogel Heberbrand, 2010, p. 297). Finally, these efforts made success stories after effectively managing to treat leptin deficiency children using the recombinant leptin protein. The treatment of leptin deficiency children also provided other insights to biomedical researchers that single gene mutations could potentially lead to disorders such as obesity and hyperphagia (Hinney, Vogel Heberbrand, 2010, p. 297). Since its discovery, leptin has posed a potential possibility for the treatment of obesity. The development of obesity treatments has been centered in identifying main targets in leptin gene which was the first to be implicated for the genetic cause of obesity. The leptin hormone is mainly secreted depending on the body fat and is responsible for the regulation of appetite and energy metabolism mainly in the brain (Ahim a, 2002, p.196). Results obtained from linkage studies have deciphered that leptin is basically an assembly of 167 different amino acids that are produced by the leptin gene right from the adipose tissue. The protein encoded by the leptin gene displays a number of biological roles associated with obesity by binding with a defined receptor located in the hypothalamus. These biological roles of leptin include the control of food intake pathways, body weight regulation and homeostasis of energy (Wang et al, 2006, p.183). French studies and investigations into populations in Pennsylvania have associated leptin to cases of severe obesity. Among humans, the chromosomal locations of the genes for leptin receptor and leptin have been mapped to 1p31 and 7q31.3 respectively (Wang et al, 2006, p.183). Research had earlier shown that the variant G-2548A occurring in the LEP promoter was responsible for reductions in the BMI among overweight women. In addition, a few studies have shown correlati ons between obesity development and the presence of LEPR gene polymorphisms (Geller et al, 2004, p.572). According to Ioffe, Moon, Connolly and Friedman (1998, p.11852), subset of obese humans have considerably lower levels of leptin plasma. The findings imply that abnormal regulation of the gene in the adipose tissue could be the main cause of pathogenesis in obesity. Ioffe et al (1998, p.11852) carried out an experiment to test the propensity that decrease in the production of leptin could impact the bodys metabolism thus cause obesity. They performed their experiment by mating animal models that carried lowly expressed adipocyte specific aP2-human leptin transgene with mice that did not express any leptin gene. The leptin treatment of the mice that never expressed leptin resulted to a marked reduction in weight which resembled the results obtained after wild-type mice treatment. Usually, a subset of obese individuals expresses relatively low levels of leptin in plasma. The decreased rates of leptin production among obese individuals by the adipocytes have been implicated for the caus e of obesity (Ioffe et al, 1998, p.11854). Mutations in the leptin gene or the leptin receptor gene have been found to cause increased appetite, overeating, massive weight gain, impaired thermoregulation, insulin resistance and diabetes, immune dysfunction, sexual maturation failures and a number of neuroendocrine derangements in both human subjects and rats (Ahima, 2002, p.196). Melanocortin-4 receptor gene (MC4R) Mutations in the melanocortin 4 receptor have been said to be the most common genetic factors which contribute to obesity. While the gene coding for the protein, MC4R has been implicated for regulating the body weight of individuals and obesity, there are no convincing reports associating the gene with the increased binge eating among obese individuals. Contrary to what had been observed in the previous studies, the MC4R deficiency does not actually cause hyperinsulinemia. However, a frameshift mutation in the gene coding for the protein MC4R has been associated with dominant human obesity (Hinney, et al, 2003, p. 4258). The protein also acts as an antagonist for the agouti-related peptide (AgRP) gene that code for an endogenous antagonist for the receptor. The homologous of the MC4R gene, the MC3R gene has also been found to be a good candidate for causing genetic susceptibility to glucose intolerance in type II diabetes mellitus (Hinney, et al, 2003, p. 4258). In order to prove tha t MC4R is influential in causing obesity, researchers have sequenced the introns of the gene among the Pima Indians who among them, 300 were severely affected by obesity and 126 of them were neither obese nor diabetic. In their study, the researchers have addressed the assertion that substitution of G-A at codon 103 of the MC4R gene is responsible for influencing abdominal obesity and lipid, glucose and insulin metabolism. The substitution has also been implicated for its effect in inflecting the circulatory hormones such as the salivary cortisol (Hinney, et al, 2003, p. 4260). Genome wide association studies (GWAS) have been potential tools for identifying a number of candidate genes in specific regions of the chromosomes which harbor genes responsible and other phenotypes (Zlot et al, 2007, p.31). GWAS also provide critical tools for indentifying the common variants with reduces penetrance relevant as traits of interests or risk factors. Genes such as melanocortin-4 receptor gene occur in a coding region which also harbors other polygenic variants which regulate weight in healthy individuals apart from the mutations responsible for obesity (Yang et al, 2002, p.20328). These minor alleles that have been identified include various polymorphisms which code for isoleucine amino acid instead of valine at position 103 (103l) and the other that codes for leucine instead of isoleucine at 251L of the receptor protein. These polymorphisms are all negatively associated with the problem of obesity (Zlot et al, 2007, p.31). Homozygous carriers of such alleles have sli ghtly reduced basal metabolic rate (BMI) which is a risk factor for obesity. The biological mechanism of the MC4R gene has been suggested to involve the activation of the MC4R receptor which leads to a significant decrease in food intake. The MC4R has therefore been marked as the main therapeutic target for obesity treatment. The new regulatory biological mechanism has also been detected in cell lines which are derived from the murine hypothalamic neurons that express MC4R endogenously. This therefore points to the physiological importance of the endocytosis promoted by AgRP. In a study involving a number of obese children and adults, 6 percent of them were found to posses MC4R SNPs (Zlot et al, 2007, p.29). Following agonist stimulation, the MC4R usually signals via the intracellular adenylate cyclase pathway of signal transduction. Studies among the obese subjects have detected large quantities of MC4R mRNA in the membranes of the astrocytes contrary to the HEK-rMC4R cell membranes. Pro-opiomelanocortin (POMC) Feeding in humans follows habitually trained rhythms which are regulated by the hypothalamus. The amount of food one consumes happens as a response to the energy status in the body that depends on the hormones. Even though this is a complex process, there exists an integrated relationship between the energy needs of the body and the amount of food that is required by the body. As a result, the brain through the hypothalamus triggers the release of responsible hormones that regulate food intake. This happens through the release of pro-opiomelanocortin (POMC) (Millinvgton, 2007, p.4). The initial stage of the production of pro-opionmelanocortin starts with the production of the release of the POMC at the hypothalamus. Through a series of active enzymatic reaction steps, the pro-opiomelanocortin (POMC) plays an initial role in the production of corticotrophin (ACTH), melanocyte-stimulating hormones (MSH) and endorphin (Millinvgton, 2007, p.4). The MSH leads to the production of melanocortin peptides that plays a high role in the development of appetite. The melanocortin peptides also continue to have a role in body weight regulation. As the body continues to produce the necessary genes that regulate its development, some genes that develop in the central nervous system give rise to the production of the melanocortin peptides. According to Zemel and Shi (2000, p.179), melanocortin peptides work by coating the melanocortin-4 receptors through the formation of a layer around these receptors. This covering inhibits the food absorption and intake. The absence of this through the degeneration of the melanocortin peptide cover marks the onset of obesity. This means that melanocortin receptors POMC peptide s plays a significant role in the development of obesity. As seen earlier, feeding is a process that happens through responses of habitual rhythms such as circadian rhythms. These rhythms are controlled by the genes that are adapted to a given type of system. The lack of POMC in the body exhibits itself through adrenal failure, altered pigmentation and increment in height onset of obesity (Millington, 2007, p.8). The processing of POMC occurs partially in the pituitary cells and neurons of the hypothalamus. However, POMC derivatives can be discharged differently through varying hypothalamic sites. These are sites that are involved in feeding process. This process of release leads to slight variations in the amount of signal sent to the sites. From the above discussion, dietary related aspects especially obesity emanates from a complex combination of various genes that makes their significant contributions. Environmental factors are also known to have their equivalent contributions to the role of the genes in the dietary habits and their effects on the body. The melanocortin that is produced as a result of POMC stimulation plays a central role in the direct processes of food absorption. Additionally, the signals sent by the POMC maintain the hormonal levels that controls amount of food to be absorbed at any given moment. This is depending on the homeostatic energy requirement at any specific time. However, in the instance when the levels of POMC released by the hypothalamus get reduced to minimal levels, the immediate effect that follows is the reduced production of melanocortin peptides. This means that the body no longer has the ability to control the amount of food being taken up by the body. Obesity develops as a resul t of the body absorbing food at a higher level than required. Prohormone convertase 1 (PCSK1) Researchers have reported that common variants in the PCSK 1 gene could be a potential cause of obesity. The proprotein convertase subtilisin/kexin type 1(PCSK 1) has been suggested to play a critical role in proteolytic cleavage, a step which is also important in the maturation process of a number of hormones which are produced as precursors (Heni et al, 2010, p.86). The PCSK 1gene codes for the prohormone convertase 1 which is actively involved in peptide maturation. The protease is selectively expressed in the endocrine and neuronal tissues where its main substrates include the hormones which regulate energy metabolism such as proinsulin, proopiomelanocortin and proglucagon (Heni et al, 2010, p.86). Rare mutations in the PCSK 1 gene have been identified to be responsible for causing childhood obesity as well as the abnormal metabolism of glucose, proinsulin and insulin and the C-peptide. Common single nucleotide polymorphisms (SNPs) in the PCSK 1 gene, the rs6232 and rs6235 have b een associated with incidences of obesity (Heni et al, 2010, p.86). Various mutations of the PCSK1 gene cause monogenic obesity. The SNP rs6235 has a high correlation to the non-synonymous rs6234 which encodes the Q665E. This substitution occurs at the protein in the C-terminal region (Tuomas et al, 2009, 3499). This research found that there exist a significant correlation between age and crs6232 in the initiation and proliferation of obesity (Tuomas et al, 2009, 3499). Another research by Qibin et al (2010, p.456) found that the rs6234 has significant association with an increased risk of a combined obesity phenotype and an overall overweight condition. The PCSK 1 gene was also found to have a higher association to obesity among men as compared to women. The result of this gene is that it influences the increment in fat storage around the waist region. The study also found that there exist enough evidence that associates PCSK1 rs6234 with overweight and the level of body mass index in men. It was also revealed that PCSK1 rs6234 plays no role in the weight gain among women. There have been various recommendations in the use of several mechanisms in the management of obesity. This has been based on the knowledge of the fact that eating habits are part of acquired characteristics. However, studies have revealed that eating habits are controlled by genes. This has therefore called for more understanding on the gene make up of a person. The understanding of the role of PCSK1 gene in the control in insulin and consequent glucose synthesis is a breakthrough in the ongoing research in the search of the appropriate weight management measures. Studies conducted by Martin et al (2010, 9) have found that small amounts of alleles of PCSK1 and SNPs are associated in high levels of stimulation of glucose proinsulin levels. This gave an indication that the two are related in the reduction of proinsulin conversion with little effect on insulin itself. Under the normal conditions, prohormone convertase cleaves a substantial amount of proinsulin. The study further found that PCSK1 and SNPs alters the sequence of the amino acid sequence of the protein which makes up this hormone. The change that is initiated by the SNP rs6232 on asparagines is the reduction of the enzymatic activity. The similar change also occurs on the location of the protein thereby reducing its effectiveness in regulating insulin. The end result is the increment of body weight, a condition that is referred to as obesity. Fat Mass and Obesity Associated Gene (FTO) The FTO gene has also been identified, using the GWAS approach, to be associated with type II diabetes and obesity. The A-allele of the FTO variant rs9939609 in intron 1 has been shown to be associated with an increased risk to develop obesity complication by 31 percent (Hinney, Vogel Heberbrand, 2010, p. 302). The association of genes in obesity and overweight problems has been suggested to be high in both monogenic obesity and polygenic forms. The FTO gene is one of the best examples of the common variants which play a role in increasing the BMI and thus important among obesity individuals. The FTO gene is known to be found in chromosome 6 among humans and variants of the gene have closely been associated with human obesity. The gene is widely distributed in both adult tissues and fetal tissues but there is much expression in the pancreatic islets as well as in the hypothalamus. Transcribed amino acid sequence of the FTO gene has shown high homology with AlkB, an enzyme which demethylates DNA oxidatively. The FTO recombinant protein has the potential to catalyze 3-methylthymine demethylation in single-stranded DNA. Animal studies have shown that gene expression in FTO is usually upregulated in rats especially in the hypothalamus following food deprivation. The gene is also negatively correlated with the orexogenic galanin like peptide expression that is commonly involved in food intake stimulation. The increase in the expression of hypothalamic FTO is often associated with energy intake regulation but not the feeding reward. These consequences make the gene to be identified as a critical in causing obesity. An obesity risk allele of the FTO variant has been identified. Usually, the carriers with a single copy of the FTO allele are more susceptible to develop obesity than individuals without the copies. In another observation, the carriers of the two copies of the FTO gene weigh even more than those with a single copy of the gene. This implies that the gene causes an increased risk of obesity among the carriers compared to those without a copy of the gene. At the same time, researchers have identified the association of the single nucleotide polymorphisms (SNPs) in the similar region (rs14210850) of the FTO gene. The variation has been identified as the cause for some percentage of population variance in BMI and even a higher number of attributable obesity cases. The risk allele, according to the researchers, is found in cluster 10 SNP in intron 1 of the FTO gene known as the rs9939609. Morbid obesity has also been shown to be associated with both the INSIG2 SNPs and the FTO gene. Varian ts of the FTO have also found to be associated with the obesity condition using GWAS of BMI. In the study, individuals with AA and AT alleles at rs993909 have been found to consume more energy per day compared to the individuals having the protective genotype of TT. However, the similar studies have indicated no variation in energy expenditure based on polymorphisms. In other studies, the consequences of variations in the two different types of SNPs in the FTO gene have shown the possibility of the gene impacting the levels of circulating leptin as well as the energy expenditure. The SNPs that affect the energy expenditure and the circulating levels of leptin include the rs1421085 and rs17817449. Although the studies have not pointed on the biological mechanisms of the FTO gene in contributing to obesity and weight control, researchers have postulated that the gene could be responsible for regulating appetite through its influence in the hypothalamus. Discussion and Recommendations The pathogenesis of complex diseases such as obesity has always been associated with the interaction of environmental and genetic factors. This complexity has made it difficult for researchers to tease apart the accurate relationship between the genotype, phenotype and environmental factors by only using conventional experimental designs. Using genetic information maintained in databases, researchers have been able to identify critical molecular pathways responsible for obesity which are specifically brought by the interaction of the environmental factors and the genetic factors (Gohlke et al, 2009, p.46). Bioinformatics techniques and the Internet have offered critical tools for synthesizing data on the relationship between genes and diseases such as obesity. Methods such as genome-wide association scans have shown a number of genetic variants in the FTO gene which might be associated with phenotypes related to obesity (Scuteri et al, 2007, p.115). Researchers have identified the po tential benefits of genomic-wide association studies (GWAS) approaches in obesity intervention and prevention strategies such as the design of highly specific drugs targeting the identified molecular pathways (Zlot et al, 2007, p. 31). The role of epigenetics in obesity has been explored by a number of researchers including McAllister et al (2009, p. 892). Epigenetics encompasses the study of a number of inheritable variations mechanisms in gene expression which do not necessarily originate from alterations in the DNA sequence. These mechanisms are often established at the early stages of postnatal development and during the prenatal stages and they act to maintain a number of gene expression patterns throughout the life of an individual (McAllister et al, 2009, p. 892). Because of this, some environmental factors have become common in the recent past and have commensurately deranged the epigenetic mechanism establishment which results in the regulation of body weight (McAllister et al, 2009, p. 892). The roles of cytosine methylation within the CpG dinucleotides, the modification of histone proteins which package the DNA into the nucleus and the cell-dependent expression of a number of autoregulatory DNA binding p roteins have been investigated and shown to perpetuate the conformation of regional chromatic which dictates which type of gene will be competent transcriptionally in specific type of cells (McAllister et al, 2009, p. 892). This literally implies that apart from the genetic basis of obesity, the epigenetic studies shed light and provides extra information that is layered above the common understanding of gene sequences. Like the DNA sequence, epigenetic factors are also replicated at cell division during mitosis and meiosis thus bestowing transgenerational epigenetic inheritance (McAllister et al, 2009, p. 892). As reported by McAllister et al (2009, p. 896), the understanding of the environmental factors on the epigenetic processes has always remained elementary. Therefore, there has been little evidence to point out specific environmental exposures whose increasing levels might affect epigenetic mechanisms. Maternal obesity has however been identified as one of the main environmental exposure which results into obesity. It is accepted that the obesity epidemic affects even the childbearing women and feed-forward transgenerational obesity amplification has been proposed to result among children born of obese mothers. This is because the intrauterine environments of obese mothers are likely to induce developmental adaptations in the developing fetus which consequently predispose them to obesity. In an observation made to support this assertion, children born of obese mother after bariatric surgery were found to have reduced risks for obesity than the children born of the same mothers before bariatric surgery (McAllister et al, 2009, p. 893). Bariatric surgery is one of the medical procedures carried out with an objective of losing weight and has shown exciting evidence in reducing the chances of obesity among the born children. There are two types of disorders that have been identified to be caused by single-gene defects. The first class of these disorders is the Mendelian disorders which cause a variety of clinical features including obesity. The second class of single-gene defects is mainly characterized by disease conditions in which obesity is one of the main clinical features. 11 different genes have been reported to be closely associated with monogenic obesity and 52 genomic regions which harbor quantitative trait loci have also been indentified to have associations with human obesity. Five of the genes have been considered to be of clinical importance since they account up to 5 percent of the early obesity onset and severe cases of childhood obesity. These genes are leptin, leptin receptor, pro-opiomelanocortin, melanocortin 4 receptor as well as prohormone convertase genes. One of the most interesting observations is that all the five genes are associated with encoding receptors and peptides involve d in satiety and appetite regulation. Therefore, there is need to intensify research efforts in marking the five genes and developing molecular drug targets for critical receptors which control appetite and satiety. Apart from the five common genes that have been associated with obesity, other minor genes with smaller effects such as ACE, LDLR and VDR have also been implicated for causing obesity. These minor genes are more than 20 in number (Bouchard, 2009, p.1499). Conclusion and Recommendation The prevalence of obesity is increasing globally as biomedical researchers step up their efforts to indentify the specific genetic causes of the epidemic. A number of technological and conceptual advances have made it possible for a shift to an approach centered in single-gene search for interventions aimed at treating and preventing obesity. Before these advances, traditional approaches involved studying obesity from the polygenic approach which was very difficult to mark out the exact molecular processes that occur in at cellular level. A few complex segregation analyses maintained the assertion that obesity was mainly caused by more than a single segregating genes having large effects on the adiposity and body weight. Later studies supported the evidence that obesity could be caused by both polygenic and oligogenic determinants. With the improved technology and scanning of the entire genome, it has been possible to identify individual genes responsible for obesity using polymorphi c microsatellite markers. Among the enabling technologies in sequencing the human genomes involve SNP identification, bioinformatics and SNP genotyping technologies. At present, these technologies have made it possible to study the anatomy of the human genome with improved details and this is expected to yield newer insights into pointing out the exact genetic causes of obesity.

Thursday Night :: essays research papers

Thursday Night When I first started college, fall two thousand two, I was not really much of a partier. I would stay in most nights, talking to friends online, or visiting someone I knew on campus. All of this changed though, one Thursday during my second semester. I was in my last class for the day, chemistry laboratory. My friend Laura, who was also in the class had been trying to convince me to go to a party with her all semester. I, all semester, had been making excuses to not go. This day though, she finally convinced me by exclaiming, "But SueEllen, it's the last party of the semester!" I succumbed to her persuasiveness and went back to my dorm to prepare. My room-mate, Melissa, was bubbling with excitement when I told her the plans for the night. So we both started getting ready. I changed into the only pair of flares I owned, and a pink tank top. I had Melissa iron my hair for me, so I could wear it down, which is something that I don't usually do. The phone rang, and it was Laura. She was outside waiting for us, it was time to go. We arrived at the hosts apartment, and the feeling that you get when you go down a steep descent in a roller coaster quickly disappeared when we were introduced to everyone there. It was a very pleasant atmosphere, partly because the people were friendly, and partly because almost everyone was slightly, if not entirely intoxicated. At some point during the night, a commotion arose as someone walked through the door into the living room. I looked up, and everyone was yelling, "Rivers!". I had seen the kid around campus before, longish black hair worn under a baseball hat, blue eyes, and a lip ring. He was cute, but whenever I had seen him, he seemed kind of withdrawn and had an angry look on his face. Everyone settled back down a moment later, and commenced socializing and drinking. A couple of hours later, I was fairly inebriated, and there weren't that many people left at the party. Everyone had gone home to get some sleep. I was fairly tired myself, and almost started to nod off while I was sitting on the couch. I woke up a little though, and started a conversation with the person sitting next to me. I don't remember exactly what we talked about, but I'm sure it was the usual introductory conversation about what bands we listened to and what classes we were taking.

Sample Question

Sample Question 5312 Fall 2009 Student:___________________________________________________________________ 1. Corporate governance include concerns about: A. business ethics and social responsibility. B. the responsibilities of the board of directors. C. equitable treatment of stakeholders. D. disclosures and transparency. E. all of the above. 2. The most powerful corporate governance legislation to date has been: A. the Sarbanes-Oxley Act (SOX) of 2002. B. the creation of the American Institute of Certified Public Accountants. C. Corporate Ethics Code of 2005. D. the regulation of inventory management practices by the SEC. . The Sarbanes-Oxley Act (SOX) of 2002 does not specifically prohibit an independent auditor from performing the following non-audit function(s) for an audit client: A. financial information systems design and implementation. B. internal audit outsourcing services. C. tax services. D. â€Å"expert† services. E. SOX specifically prohibits an independent audi tor from performing all of all of the non-audit services for an audit client. 4. Which is the following descriptions is not one of the â€Å"Seven Financial Shenanigans† identified by Howard Schilit and listed in Exhibit 10-1: A. ecording revenue too soon or that is of a questionable quality. B. boosting income with one-time gains. C. failing to record intangible assets which the company has ownership rights to. D. shifting future expenses to the current period as a special charge. E. failing to record or improperly reducing liabilities. 5. The explanatory notes to the financial statements: A. should be referred to if more than a cursory, and perhaps misleading impression of a firm's financial position and its results of operations is to be achieved. B. are not an integral part of the financial statements. C. nclude a great deal of detailed information that is potentially useful only to a financial analyst making a detailed appraisal of the future prospects of the entity. D. are used by many entities to hide information from the reader of the financial statements by including in the explanatory notes information that should be shown in detail on the financial statements themselves. 6. The nature and content of disclosures relate to all of the following except: A. accounting changes. B. segment information. C. fair market value. D. contingencies and commitments. E. events subsequent to the balance sheet date. . Which of the following is nota topic that is likely to be discussed as a significant accounting policy? A. Depreciation method. B. Earnings per share of common stock calculation details. C. Inventory valuation method. D. Method of estimating uncollectible accounts receivable. 8. The explanatory notes to the financial statements: A. are not an integral part of the financial statements. B. explain the significant accounting policies of the company. C. usually disclose the amount of the company's bad debts expense. D. describe management's product de velopment plans for the coming year. 9.Significant accounting policies are described in the explanatory notes to the financial statements because: A. there isn't enough space for them to be included in the captions of the financial statements. B. if the accrual basis of accounting is used, â€Å"matching† of revenues and expenses may not take place. C. the reader must be aware of which of the alternative generally accepted accounting practices have been used. D. none of the above. 10. When an entity changes its accounting from one generally accepted method to another generally accepted method: A. financial statements of all prior years are changed to maintain comparability. B. n explanatory note stating that the change was approved by the Financial Accounting Standards Board is required. C. the dollar effect of the change on both the balance sheet and income statement must be disclosed. D. changes like this are not permitted. 11. The impact of changing price levels on amounts reported in financial statements is: A. reported as a separate item on the balance sheet. B. accomplished by reporting assets at their replacement cost. C. required to be described in the explanatory notes to the financial statements. D. encouraged, but not required to be described in the explanatory notes to the financial statements. 2. Management's statement of responsibility: A. explains that the entity's financial statements are the responsibility of the entity's auditors. B. states that the financial statements are free of significant error. C. affirms that management is responsible for assuring adherence to internal control policies and procedures. D. guarantees that the firm has operated in a highly ethical manner. 13. Firms that issue registered securities are required to file, with the SEC on an annual basis, which of the following? A. An annual report. B. A prospectus. C. A form 10-K. D. A set of financial statements. E.All of the above. 14. A firm's cash dividends were $ 3. 96 per share of common stock for calendar 2006. In 2007 the stock was split 3 for 1, and in 2008 a 10% stock dividend was issued. Dividends per share for 2006, to be reported in the firm's annual report for 2008, are: A. $3. 96 B. $1. 45 C. $1. 32 D. $1. 20 15. Business segment information is included in the explanatory notes to financial statements because: A. the amounts shown on the financial statements of most companies are just too large to comprehend. B. current and potential investors can make more informed judgments about the company. C. et income from various geographic areas can be clearly determined. D. by combining these amounts for each segment, ROI and funds flows for the company as a whole can be determined. 16. For 2006, Skresso Co. reported $3. 64 of earnings per share of common stock. During 2007 the firm had a 4% common stock dividend. 2006 earnings per share to be reported in the annual report for 2007 are: A. $3. 79 B. $3. 64 C. $3. 50 D. $3. 49 17. Managemen t's statement of responsibility: A. usually refers to the company's system of internal controls. B. emphasizes that the auditors are responsible for the financial statements. C. ncludes a disclaimer of responsibility for the level of the P/E ratio of the company's common stock. D. gives the president of the company an opportunity to explain why profits changed. 18. Which of the following is the proper paragraph sequence for an independent Auditor's Report? A. Scope, introduction, opinion. B. Introduction, scope, opinion. C. Opinion, scope, summary. D. Introduction, opinion, scope. 19. A firm's independent auditors have the responsibility to: A. assess the firm's accounting policies. B. ascertain the firm's profit potential. C. uncover all fraudulent activities. D. assess management's discussion and analysis. 0. The independent auditors' report usually: A. presents a â€Å"clean bill of health† for the company. B. refers to the quality of the company's products or services. C. includes an opinion that the financial statements are correct. D. includes an opinion that the financial statements present fairly, in all material respects, financial information about the company. 21. An audit conducted in accordance with generally accepted auditing standards includes each of the following except: A. examination, on a test basis, of evidence supporting the amounts and disclosures in the financial statements. B. valuation of the efficiency and effectiveness of management. C. assessment of the accounting principles used and significant estimates made by management. D. planning and performance of the audit to obtain reasonable assurance that the financial statements are free of material misstatements. 22. Which one of the following methods is no longer a Generally Accepted Accounting Method? A. Purchase accounting. B. Fair market value method. C. Pooling method. D. None of the Above. 23. Which of the following require an explanatory note in the independent auditors' report. A. basing the opinion on the work of another auditor.B. Uncertainties about the outcome of a significant event that would have affected the presentation of the financial statement. C. Substantial doubt about the entity's viability to continue as a going concern. D. None of the above. E. Items a, b and c are correct. 24. A management that wanted to increase the financial leverage of its firm would: A. raise additional capital by selling common stock. B. use excess cash to purchase preferred stock for the treasury. C. raise additional capital by selling fixed interest rate long-term bonds. D. try to increase its ROI by increasing asset turnover. 25.For the fiscal year ended March 31, 2007, a company reported earnings per share of $3. 25 and cash dividends per share of $0. 50. During fiscal 2008, the company had a 3 for 2 stock split. In the annual report for the fiscal year ended March 31, 2008, earnings per share and cash dividends for fiscal 2007 would be reported, respecti vely, as: A. $3. 25 and $0. 50 B. $4. 85 and $0. 75 C. $2. 17 and $0. 33 D. $1. 09 and $0. 17 26. Financial leverage: A. arises because most borrowed funds have a fixed interest rate. B. arises because most borrowed funds have a variable interest rate. C. usually has no bearing on the risk associated with a company.D. is a concept that does not apply to individuals. 27. A potential creditor's judgment about granting credit would be most influenced by the potential customer's: A. current ratio at the end of the prior fiscal year. B. most recent acid-test ratio. C. trend of acid-test ratio over the past three years. D. practice with respect to taking cash discounts offered by current suppliers. 28. Another term for the price/earnings ratio is: A. cost ratio. B. sales multiple. C. earnings multiple. D. profit ratio. 29. An entity's current ratio will be influenced by: A. the inventory cost flow assumption used. B. riting off an overdue account receivable against the allowance for uncol lectible accounts. C. the depreciation method used. D. issuance of a stock dividend. 30. If a firm's debt ratio were 25%, its debt/equity ratio would be: A. 25%. B. 50%. C. 33. 33%. D. 75%. 31. An individual interested in making a judgment about the profitability of a company should: A. review the trend of working capital for several years. B. calculate the company's ROI for the most recent year. C. review the trend of the company's ROI for several years. D. compare the company's ROI for the most recent year with the industry average ROI for the most recent year. 2. Which of the following is not a category of financial statement ratios? A. Financial leverage. B. Liquidity. C. Profitability. D. Prospectus. 33. When a firm has financial leverage: A. ROI will be greater than ROE. B. ROI will usually be less than it would be without leverage. C. risk is greater than if there isn't any leverage. D. the firm will always have a higher ROE than it would without leverage. 34. When a corporat ion has both common stock and preferred stock outstanding: A. dividends on preferred stock are paid only if the company has current earnings. B. ividends on preferred stock must be paid before dividends on common stock can be paid. C. preferred stockholders receive the same dividend per share as common stockholders. D. dividends on preferred stock are paid only if dividends are to be paid on the common stock. 35. A leverage buyout refers to: A. one firm issues stock to take over another firm. B. one firm trades its stock for the stock of another firm. C. a firm goes heavily into debt in order to obtain the funds to purchase the shares of the public stockholders. D. one firm pays cash for the shares of a takeover firm's shares. 36.The dividend payout ratio describes: A. the proportion of earnings paid as dividends. B. the relationship of dividends per share to market price per share. C. the percentage change in dividends this year compared to last year. D. dividends as a percentage o f the price/earnings ratio. 37. The price/earnings ratio: A. is a measure of the relative expensiveness of a firm's common stock. B. does not usually change by more than 1. 0 (e. g. 8. 2 to 9. 2) during the year. C. can be used to determine the cash dividend to be received during the year. D. is calculated by dividing the earnings multiple by net income. 38.If a firm's payment terms for sales made on account to its customers were 2/10, n30, the number of days' sales in accounts receivable would be expected to be: A. less than 10. B. between 10 and 25. C. between 25 and 40. D. over 40. 39. A common size income statement: A. uses the same dollar amount of revenues for each year. B. expresses items as a percentage of revenues. C. makes comparisons between years more difficult. D. is useful in estimating the impact of inflation. 40. Management's use of resources can best be evaluated by focusing on measures of: A. liquidity. B. activity. C. leverage. D. book value. 41.Asset turnover cal culations: A. are made by dividing the average asset balance during the year by the sales for the year. B. are made by dividing sales for the year by the asset balance at the end of the year. C. communicate information about how promptly the entity pays its bills. D. should be evaluated by observing the turnover trend over a period of time. 42. The comparison of activity measures of different companies is complicated by the fact that: A. different inventory cost flow assumptions may be used. B. dollar amounts of assets may be significantly different. C. only one of the companies may have preferred stock outstanding.D. the number of shares of common stock issued may be significantly different. 43. A higher P/E ratio means that: A. the stock is more reasonably priced. B. the stock is relatively expensive. C. investors are wary of the stock. D. earnings are expected to decrease. 44. Which of the following is(are) an example of a measure of leverage? A. Debt yield. B. Debt payout ratio. C. Preferred dividend coverage ratio. D. Debt/equity ratio. E. All of the above. 45. The inventory turnover calculation: A. is wrong unless cost of goods sold is used in the numerator. B. is wrong unless sales is used in the numerator. C. s an alternative way of expressing the number of days' sales in inventory. D. requires knowledge of the inventory cost flow assumption being used. 46. Book value per share of common stock of a manufacturing company: A. is not a very useful measure most of the time. B. is calculated by dividing market value per share by earnings per share. C. reflects the fair market value of the company's stock. D. is the same as the total balance sheet asset value per share of common stock. 47. If the P/E ratio of a company's common stock were 12, and its earnings were $ 2. 50 per common share: A. the market value of the common stock would be $20. 3 per share. B. the market value of the common stock would be $25. 00 per share. C. an increase in earnings of $0. 20 per share, with no change in the multiple, would result in a market price increase of $2. 40 per share. D. an increase in earnings of $0. 20 per share, with no change in the multiple, would result in a market price increase of $1. 67 per share. 48. The concept of operating leverage refers to which of the following? A. Operating income changes proportionately more than revenues for any given change in activity level. B. Operating income changes proportionately less than revenues for any given change in activity level.C. Operating income changes proportionately more than income for any given change in activity level. D. Operating income changes proportionately less than income for any given change in activity level. 49. As the total volume of activity changes: A. the total of variable costs changes. B. the total of fixed costs changes. C. variable costs per unit change. D. fixed costs per unit stay the same. 50. A firm has revenues of $120,000, a contribution margin ratio of 30%, and fixed expenses that total $56,000. If revenues increase $20,000, then: A. operating income will increase by $6000. B. operating income will be 0.C. fixed expenses will increase $8000. D. the contribution margin ratio will increase by 1/8. 51. Each of a company's several product lines has a different contribution margin ratio. Total sales in 2007 were 20% higher than total sales in 2006. Total contribution margin for 2007 will be: A. the same as it was in 2006, regardless of changes in sales mix. B. 20% higher than it was in 2006, regardless of changes in sales mix. C. more than 20% higher than it was in 2006, if the sales mix changes and proportionately more high contribution margin ratio products are sold in 2007 than in 2006. D. ess than 20% higher than it was in 2006, if the sales mix changes and proportionately more high contribution margin ratio products are sold in 2007 than in 2006. For questions 52, 53, 66, 79 and 84 the following graph is needed. [pic] 52. If sales volume were to decrease 10%, from 4,000 units per month to 3,600 units per month, operating income would: A. not change B. decrease $10,000 C. decrease $24,000 D. decrease $40,000 53. If the selling price per unit were to drop $2, from $100 to $98, the sales volume were to increase 500 units to 4,500 units per month, and advertising expense were to increase by $1,000: A. he break-even point would increase. B. the break-even point would decrease. C. the contribution margin ratio would increase. D. operating income would decrease. 54. The cost of a single unit of production in excess of the breakeven point in units is: A. its fixed cost and variable cost. B. its fixed cost only. C. its variable cost only. D. none of the above. For questions 55 and 64 the following graph is needed. [pic] 55. Using the high-low method, the variable rate for maintenance is: A. $0. 40 B. $0. 80 C. $1. 20 D. $2. 50 56. The term â€Å"relevant range† refers to: A. the range of activity where costs will fluc tuate. B. he range of activity where fixed costs change as activity changes. C. the range of activity where total variable cost remains constant as activity changes. D. the range of activity where cost relationships are valid. 57. A firm's products have an average contribution margin ratio of 40%, which will be maintained for the next month even though fixed expenses are expected to rise by $20,000. In order to keep operating income for the month from being affected, revenues will have to increase by: A. $ 8,000 B. $12,000 C. $20,000 D. $50,000 58. The cost formula for monthly customer order processing cost has been established as $100 + $0. 5 per order. It is expected that 5,600 orders will be processed in May and 6,400 in June. Total order processing costs for May and June combined will be estimated to be: A. $ 940 B. $1,060 C. $2,000 D. $2,500 59. The contribution margin ratio always decreases when the: A. breakeven point decreases. B. fixed expenses increase. C. selling price in creases and the variable costs remain constant. D. variable cost increase and the selling price remains constant. 60. Knowledge about the behavior pattern of a cost is important to understanding the effect on net income of a change in sales volume because as sales volume changes: A. et income will change proportionately. B. the effect on net income will depend on the behavior pattern of various costs. C. fixed costs will rise proportionately. D. variable costs will not change. 61. Management accounting is: A. a highly technical subject that people in personnel or engineering should not be expected to understand. B. performed by individuals who seldom work with people in other functional areas of the organization. C. the principal activity involved in determining the goals and objectives of the entity. D. an activity that gets involved with virtually all of the other functional areas of the organization. 62.What percentage of the contribution margin is profit on units sold in excess of the breakeven point? A. It's 50% to the contribution margin ratio. B. It's equal to the variable cost ratio. C. It's equal of the gross profit ratio. D. It's 100%. 63. ABU Co. has several products, each with a different contribution margin ratio. If the same number of units were sold in July as in June, but the sales mix changed: A. operating income would be the same in June and July. B. fixed expenses in July would be in a different relevant range than in June. C. the company's overall contribution margin ratio would be the same in June and July.D. total contribution margin in July would be different from that in June. 64. Using the high-low method, the monthly fixed component of maintenance cost is: A. $1,600 B. $1,200 C. $1,100 D. $1,300 65. When the cost behavior pattern has been identified as fixed at a certain volume of activity: A. any change in volume will probably cause the cost to change. B. it is appropriate to express the cost on a per unit of activity basis. C. the t otal cost will not change even if the volume of activity changes substantially. D. the total cost may change if the volume of activity changes substantially. 66.The break-even point volume of units is: A. 0 B. 360 C. 720 D. 1000 67. An example of a cost likely to have a fixed behavior pattern is: A. sales force commission. B. production labor wages. C. advertising cost. D. electricity cost for packaging equipment. 68. The formula for expressing the total of a fixed, variable, or mixed cost at any level of activity is: A. total cost = fixed cost + (variable rate * volume of activity) B. total cost = fixed cost * volume of activity C. total cost = fixed cost * variable rate D. total cost = fixed cost – variable cost 69. As the level of activity decreases: A. fixed cost per unit decrease.B. variable cost per unit decrease. C. fixed cost remains constant in total. D. variable cost remains constant in total. 70. The contribution margin format income statement is organized by: A. r esponsibility centers. B. functional classifications. C. sales territories. D. cost behavior classifications. 71. As the level of activity increases: A. fixed cost per unit increase. B. variable cost per unit increase. C. variable cost per unit decrease. D. fixed cost per unit decrease. 72. Managerial accounting supports the management process most significantly by: A. measuring and reporting financial results after the fact.B. determining the goals and objectives of the entity. C. providing estimates of financial results for various plans. D. establishing operating policies to be followed during a period of time. 73. An example of a cost that is likely to have a variable behavior pattern is: A. sales force salaries. B. depreciation of production equipment. C. salaries of production supervisors. D. production labor wages. 74. A 10% change in a firm's revenues is likely to result in a change of more than 10% in the firm's operating income because: A. not all of the firm's costs will change in proportion to the revenue change.B. the firm has financial leverage. C. the contribution margin ratio will change in proportion to the revenue change. D. only fixed expenses will change in proportion to the revenue change. 75. An example of a cost likely to have a mixed behavior pattern is: A. sales force commission. B. raw material cost. C. depreciation of production equipment. D. electricity cost for the manufacturing plant. 76. Cost behavior refers to: A. costs that are both good and bad. B. costs that increase at a quicker rate than others. C. costs that decrease at a quicker rate than others. D. costs that are variable or fixed. E. one of the above. 77. Which of the following statements doesnot describe a characteristic of management accounting? A. Management accounting must conform to GAAP. B. Approximate amounts rather than accurate amounts or refined estimates are often used in management accounting. C. Management accounting places a great deal of emphasis on the f uture. D. Management accounting is more concerned with units of the organization rather than with the organization as a whole. 78. Simplifying assumptions made when using cost behavior pattern data include: A. relevant range and liquidity. B. fixed activity and linearity.C. relevant range and linearity. D. activity range and variability. 79. The contribution margin ratio is: A. 40% B. 60% C. 62. 5% D. 70% 80. Which of the following terms do not appear on the contribution margin format income statement: A. gross profit. B. contribution margin. C. operating income. D. variable expenses. 81. A management decision that would have a long term influence on the operating leverage of a firm would be: A. increasing the advertising budget. B. substituting robots for hourly paid production workers. C. increasing prices in proportion to raw material cost increases.D. having a season-end sale of seasonal products. 82. Which of the following activities is not part of the management planning and c ontrol cycle: A. data collection and performance feedback. B. implementation of plans. C. providing information to investors and creditors. D. revisiting plans. 83. The relevant range concept refers to: A. a firm's range of profitability. B. a firm's range of sales. C. a firm's range of rates of return. D. a firm's range of activity. 84. The break-even point in terms of total revenues per month is: A. $30,000 B. $60,000 C. $75,000 D. $100,000 85.When the high-low method of estimating a cost behavior pattern is used: A. cost and volume data must be reviewed for outliers. B. the direct result of the high-low calculations is the fixed expense amount. C. the highest and lowest sales price and volume amounts are used in the calculation. D. the resulting cost formula will explain total cost accurately for every value between the high and low volumes. 86. The shift in the amount of manufacturing overhead costs applied to the mix of products produced that occurs when using a single cost dri ver rate as compared to using activity-based costing rates is known as: A. nderapplied overhead B. overapplied overhead C. cost absorption D. cost distortion 87. An excess of cost of goods manufactured over cost of goods sold for the period represents: A. an increase in gross profit. B. a decrease in work in process inventory. C. overapplied manufacturing overhead. D. an increase in finished goods inventory. 88. A predetermined overhead rate is used to: A. keep track of actual overhead costs as they are incurred. B. assign indirect costs to cost objects. C. establish prices for manufactured products. D. allocate selling and administrative expenses to manufactured products. 9. Which of the following will cause income determined with absorption costing to be higher than income determined with direct costing? A. units produced equals units sold. B. units produced is greater than units sold. C. units produced is less than units sold. D. income determined with absorption costing will alw ays equal income determined with direct costing. 90. The overhead component of product cost is: A. the sum of the actual overhead costs incurred in the manufacture of the product. B. likely to be the same amount for every product made by the company. C. n estimated amount based on labor hours, machine hours, or some other activity. D. determined at the end of the year when actual costs and actual production are known. 91. For the partial value chain functions given below, which sequence is correct? A. design, production, marketing B. marketing, production, distribution C. research and development, production, distribution D. customer service, marketing, distribution 92. Total manufacturing costs for the month on the statement of costs of goods manufactured equals: A. variable costs + fixed costs + mixed costs. B. work in process inventory – finished goods inventory.C. cost of goods sold – cost of goods manufactured. D. cost of raw material used + direct labor cost incu rred + manufacturing overhead applied. 93. An example of a cost likely to have an indirect relationship with products being manufactured: A. production labor costs. B. raw material costs. C. electricity costs for packaging equipment. D. none of the above. 94. Costs may be allocated to a product or activity for many purposes, but care must be exercised when using allocated costs because: A. direct costs identified with the product or activity may not be accurately assigned.B. fixed costs will change in total if the volume of activity changes. C. all costs may not have been allocated to the product or activity. D. arbitrarily allocated costs may not behave in the way assumed in the allocation method. 95. The production cost of a single unit of a manufactured product is determined by: A. dividing total direct materials and direct labor for a production run by the number of units made. B. dividing total direct materials, direct labor, and manufacturing overhead for a production run by t he number of units made. C. ividing total direct materials, direct labor, manufacturing overhead and selling expenses for a production run by the number of units made. D. dividing the selling price by the gross profit ratio. 96. An example of a cost that is likely to have a direct relationship with products being manufactured: A. sales force salaries. B. depreciation of production equipment. C. salaries of production supervisors. D. production labor costs. 97. The sequence of activities that add value to the organization are: A. the value processes. B. the chain of production events. C. the value chain. D. the strategic cost initiatives. 8. Which of the following activities is not included in the organization's value chain? A. marketing. B. finance. C. customer service. D. research and development 99. Cost accounting is a subset of: A. financial accounting. B. process cost accounting. C. job order cost accounting. D. managerial accounting. 100. The three components of product costs are: A. direct material, supervisor salaries, selling expenses. B. direct labor, manufacturing overhead, indirect material. C. direct material, manufacturing overhead, direct labor. D. manufacturing overhead, indirect material, indirect labor.

Agricutlral machinery Greece essays

Agricutlral machinery Greece essays The agriculture of Hellensitic Italy was transformed not only by the introduction of a large number of technical innovations, but also by a profound structural change. The last 2 centuries BC witnessed decisive steps towards the establishment of large scale estates, latifundia, which were to play an important role in the course of the empire. Even though the cultivation units remained relatively small for a long period, there was gradual transition to more extensive farming, largely based on slave labour. Fortunately, we are able to gain a detailed insight into the agricultural life of the time. About 160BC, a Roman statesman, Cato the Censor (234BC-149BC) wrote a book called De agricultura ("About Agriculture"). It is not a well arranged manual, but rather a collection of unconnected notes comprising, apart from general instructions and a mention of religious customs, a description of two of Cato's own estates near the border of Latium and Campania. One farm - with an extent of 240 iugera (about 60ha. or 150 acres), managed by 13 people (mainly slaves) - specialised in the cultivation of olives. The other specialised in viticulture, occupied 100 iugera (about 25ha. or 60 acres) and was managed by 16 people. Even though the descriptions refer to these two particular farms, they are doubtless fairly representative of normal cultivation units in Late Republican Italy. Besides workers and animals, all kinds of tools and equipment are listed, including the precise number of spades, axes, tongs, working tables and so on used at each farm. As well as this, specialised agricultural equipment, Cato describes a series of machines, showing that - in spite of his well-known aversion to everything foreign - he was perfectly aware of the recent The olives were crushed in 5 edge-runner mills (trapeta1) of various sizes (a recent invention), and the pulp was then transferred to five presses of the most recent models, ...

Applied Law Example

Applied Law Example Applied Law – Coursework Example Applied Law The contract created by the Police Commissioner when he offers $100,000 reward is aunilateral contract. Unlike bilateral contract, a unilateral contract does not encompass a two-party agreement (Linn 81). The commissioner drafts the contract and presents it already containing the applicable terms and conditions. In this respect, whoever provides the information that leads to the solution of the murder case is not involved in the making of the contract.Mary does not need to testify in order to get the reward money. According to the Police Commissioner, what is needed is the information that can lead to the arrest and conviction of the offender. Once the arrest is made and the crime against the perpetrator confirmed, then Mary should get the reward money. The only important factor is ensuring that the police have the person they are looking for.Bob can actually claim a portion of the reward money if not all. This is because no exceptions were made by the commissioner detail ing police officers were not eligible for the reward. However, if Mary can prove foul play by Bob, then the issue can be argued against Bob getting part of or all the reward money. Essentially, he played a critical role in the apprehension of the crime perpetrator.The relevant rule in this case is informed by judicial decision(s). In this respect, policy consideration relevant to a case stands by the principles, statutes, or precedents that the judicial system observes relative to the matter at hand (Linn 109). personally, I agree with the policy. This is because the law should be allowed to take its course.Linn, Edith. Arrest Decisions: What Works for the Officer? New York: Peter Lang, 2009. Print.

Enzyme Activity Essay Example | Topics and Well Written Essays - 1000 words

Enzyme Activity - Essay Example This helps in enhancing the lively activities of the living beings. The free radical formation is an important cause in causing and increasing a disease. The enzymes that act as scavengers and remove ROS can help in preventive methods of some critical diseases. The investigations regarding the enzymes that are critical for the bacterial existence provide information about physiology of microbes. The understanding of cell metabolism, evolution of bacteria and the interactions between bacterium and host can be enhanced. With this information it is possible to explain the mechanisms that regulate the organism and to find out the proteins that are necessary of existence of the cell. According to Brendan Burns, George Mendz and Stuart Hazell in the case of CAA the resonances arising from -CH and -CH2 groups of the aspartate moiety have chemical shifts and coupling constants different from those of the amino acid aspartate. Thus, it was possible to make an unambiguous assignment of CAA.2 The investigations in other enzymes lack this type of identification in case of complex activities. Regarding the results related to the study of enzymes in H Pylori the NMR method will give good results when combined with radio active tracer analysis and spectrophotometry. The activity of the enzyme in the development of H pylori is useful in developing therapeutic drugs as it was found essential for existence and growth of H Pylori. The above activity was related to the enzyme investigation regarding the existence of disease causing bacteria. There are number of enzymes with varying activities. Some enzymes even effect the skeletal in animals (as well as in human beings). These activities are studied to solve the problems regarding the muscle problems. After the structure (skeleton) of the human body the muscle is the thing, which contributes strength and movement for it. The enzymes, which affect the fibre and the muscle, play an important role in developing methods to increase or preserve the efficiency of the muscle fibre. There are 3 types of fibres according to P. D. Gollnick, R.B. Armstrong, C.W.Saubertiv, K. Piehl, and B. Stalin (1972). These fibres are interconvertibility depends on the training given. The training proved to increase red muscle at the expense of white muscle. This means that the enzyme activity was changed due to training as the enzymes acting in the existence of red and white muscles are different. FIG. 1. Serial sections from vastus lateralis muscle stained for DPNH-diaphorase (lop) and rnyosin ATPase (boltom) from four sub- jects. A and B: untrained middle-aged subject (BA). Note relatively large fibers and light DPNH-diaphorase stain in both FT and

Advertisement Essay Example | Topics and Well Written Essays - 250 words

Advertisement - Essay Example Nevertheless, the brilliant thing about advertising is that it works on a subconscious level, this means that one may think the advertisement has had no effect on them but the message conveyed through the advertisement instills in the brain without notice. Examples of this type of advertising include the coca cola advert of someone drinking coca cola in the middle of the desert, which induces the connection between coca cola and thirst in one’s mind. Moreover, people are generally attracted to new things, as the common saying says, â€Å"the new is always better than the old†. Customers in many ways follow this saying in that anyone who sees a new brand or version advertised; they are keen to try it. For example, even if one is happy with their current brand of toothpaste and they come across a new version of it that promotes their whiter teeth, one will be keen to try it even if it is just to disprove